GIA Publications

• Neugebauer, V., Ponomarev, I. Alcohol withdrawal and pain: Peripheral mechanisms join central circuits. Neuron 112: 1-3, 2024. PMID: 38176389.

• Pourghaed, M., Sarangi, A., Ramirez-Velandia, F., Kopel, J., Culberson, J., Ashworth, G., Khan, H., Boles, A., Neugebauer, V., Lawrence, J.J. Associations between Vitamin D Deficiency/Insufficiency and Depression Expose Health Disparities in Older Rural West Texans: A Project FRONTIER Study. Am. J. Geriatr. Psychiatry S1064-7481(24)00040-X, 2024. PMID: 38320908.

• Shen, C.L., Wang, R., Santos, J.M., Elmassry, M.M., Stephens, E., Kim, N., Neugebauer, V. Ginger alleviates mechanical hypersensitivity and anxio-depressive behavior in rats with diabetic neuropathy through beneficial actions on gut microbiome composition, mitochondria and neuroimmune cells of colon and spinal cord. Nutrition Research, 2024.

• Notartomaso, S., Antenucci, N., Mazzitelli, M., Rovira, X., Boccella, S., Ricciardi, F., Liberatore, F., Gomez-Santacana, X., Imbriglio, T., Cannella, M., Zussy, C., Luongo, L., Maione, S., Goudet, C., Battaglia, G., Llebaria, A., Nicoletti, F., Neugebauer, V. A "double-edged" role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs. bioRxiv. 2024 Jan 3:2024.01.02.573945. doi: 10.1101/2024.01.02.573945, 2024. Preprint. PMID: 3826042.

• Mazzitelli, M., Ponomareva, O., Presto, P., John, J., Neugebauer, V. Impaired amygdala astrocytic signaling worsens neuropathic pain-associated neuronal functions and behaviors. Front. Pharmacol., 2024.

• Shen, C.-L., Santos, J.M., Elmassry, M.M., Bhakta, V., Driver, Z., Ji, G., Yakhnitsa, V., Kiritoshi, T., Lovett, J., Hamood, A.N., Sang, S., Neugebauer, V. Ginger polyphenols mitigate hypersensitivity in neuropathic pain rats by reversing the molecular signature of amygdala neuroimmune signaling: implication of microbiome-gut-brain-axis. Antioxidants, 2024.

• Shen, C.-L., Deshmukh, H., Santos, J.M., Elmassry, M.M., Presto, P., Driver, Z., Bhakta, V., Yakhnitsa, V., Kiritoshi, T., Ji, G., Lovett, J., Hamood, A.N., Neugebauer, V. Fecal microbiota transplantation attenuates mechanical hypersensitivity in rats with neuropathy via modulation of gut microbiome, suppression of microglial activation and inflammation in colon and brain: microbiota-gut-brain axis. Front. Med., 2024.

• Neugebauer, V., Kiritoshi, T. Cortico-limbic plasticity in pain – Hippocampus joins the party. Pain, 2023. doi: 10.1097/j.pain.0000000000003101. PMID: 37889585. NIHMSID 1936477.

• Santos, J.M., Wang, R., Bhakta, V., Driver, Z., Yakhnitsa, V., Kiritoshi, T., Ji, G., Neugebauer, V., Shen, L. Turmeric bioactive compounds alleviate spinal nerve ligation-induced neuropathic pain via suppressing glial activation and improving mitochondrial function in spinal cord and amygdala. Nutrients 15 4403 (15 pp), 2023. PMID: 37892476. PMC10610406.

• Fadalla, C., Singer, J., Ashworth, G., Boles, A., Burugu, D., Molinar-Lopez, V., Neugebauer, V. Longstanding Rural-Urban Disparities Exacerbated by COVID-19: The Experiences of Older Residents in West Texas and Lesson Learned. Epidemiol. Int. J. 7: 000265 (13 pp), 2023.

• Navratilova, E., Qu, C., Ji, G., Neugebauer, V., Guerrero, M., Rosen, H., Roberts, E., Porreca, F. Opposing effects on descending control of nociception by mu and kappa opioid receptors in the anterior cingulate cortex. Anesthesiology, 2023. PMID: 37725756.

• Singh, S.P., Guindon, J., Mody, P.H., Ashworth, G., Kopel, J., Chilakapati, S., Adogwa, O., Neugebauer, V., Burton, M.D. Pain and Aging: A unique challenge in neuroinflammation and behavior. Mol. Pain. 19: 17448069231203090 (18 pp), 2023. PMID: 37684099. PMC10552461.

• Kopruszinski, C.M., Watanabe, M., Martinez, A.L., Moreira de Souza, L.H., Dodick, D.W., Moutal, A., Neugebauer, V., Porreca, F., Navratilova, E. Kappa opioid receptor agonists produce sexually dimorphic and prolactin-dependent hyperalgesic priming, Pain 164:e263-e273, 2023. PMID: 36625833.

• Neugebauer, V., Presto, P., Yakhnitsa, V., Antenucci, N., Mendoza, B., Ji, G. Pain-related cortico-limbic plasticity and opioid signaling. Neuropharmacology 231:109510, 2023. PMID: 36944393.

• Nia, S.S., Hossain, M.A., Ji, G., Jonnalagadda, S.K., Obeng, S., Rahman, M.A., Sifat, A.E., Nozohouri, S., Blackwell, C., Patel, D., Thompson, J., Runyon, S., Hiranita, T., McCurdy, C.R., McMahon, L., Abbruscato, T.J., Trippier, P.C., Neugebauer, V., German, N.A. Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands. Eur. J. Med. Chem. 254: 115309, 2023. PMID: 37054561.

• Singer, J., Rerick, P., Elliott, L., Fadalla, C., McLean, E., Molinar-Lopez, V., Neugebauer, V. Investigating the relationship between marital status and ethnicity on neurocognitive functioning in a rural older population: A Project Frontier study. J. Gerontol. B Psychol. Sci. Soc. Sci., 2023 (in press).

• Presto, P., Ji, G., Ponomareva, O., Ponomarev, I., Neugebauer, V. Hmgb1 silencing in the amygdala inhibits pain-related behaviors in a rat model of neuropathic pain. Int. J. Mol. Sci., 24: 11944 (28 pp), 2023 (in press). 

• Shen, C.-L., Newman, J.W., Elmassry, M.M., Borkowski, K., Chyu, M.-C., Kahathuduwa, C., Neugebauer, V., Watkins, B.A. Tai Chi exercise reduces circulating levels of inflammatory oxylipins in postmenopausal women with knee osteoarthritis: results from a pilot study. Front. Med., 2023 (in press).

• Shen, C.-L., Wang, R., Yakhnitsa, V., Santos, J., Watson, C., Kiritoshi, T., Ji, G., Hamood, A., Neugebauer, V. Gingerol-enriched ginger supplementation mitigates neuropathic pain via mitigating intestinal permeability and neuroinflammation: gut-brain connection. Front. Pharmacol. 13: 912609 (10 pp.), 2022. PMID: 35873544. PMC9305072 

• Mazzitelli, M., Presto, P., Antenucci, N., Meltan, S., Neugebauer, V. Recent Advances in the Modulation of Pain by the Metabotropic Glutamate Receptors. Cells 11: 2608 (40 pp), 2022. PMID: 36010684; PMC9406805.

• Shen C.-L., Wang R., Yakhnitsa V., Sanos J., Watson C., Kirtoshi T., Ji G., Hamood A., Neugebauer V. Gingerol-enriched ginger supplementation mitigates neuropathic pain via mitigating intestinal permeability and neuroinflammation: gut-brain connection. Front. Pharmacol., 2022

• Shen, C.-L., Castro, L., Fang, C.-Y., Castro, M., Sherali, S., White, S., Wang, R., Neugebauer, V. Bioactive compounds for neuropathic pain: an update on preclinical studies and future perspectives. J. Nutr. Biochem. 104: 108979 (29 pp.), 2022 PMID: 35245654.

• Presto, P., Mazzitelli, M., Junell, R., Griffin, Z., Neugebauer, V. Sex differences in pain along the neuraxis.  Neuropharmacology 210: 109030 (14 pp.), 2022.  PMID: 35331712.

• Mazzitelli, M., Yakhnitsa, V., Neugebauer, B., Neugebauer, V. Optogenetic manipulations of CeA-CRF neurons modulate pain-and anxiety-like behaviors in neuropathic pain and control rats.  Neuropharmacology 210: 109031 (12 pp.), 2022.  PMID: 35304173.

• Shen, C.-L., Schuck, A., Tompkins, C., Dunn, D.M., Neugebauer, V. Bioactive compounds for fibromyalgia-like symptoms: a narrative review and future perspectives. Int. J. Environ. Res. Public Health 19:4148 (17 pp), 2022. PMID: 35245654. PMC8998198.

• Ito, H., Navratilova, E., Vagnerova, B., Watanabe, M., Kopruszinski, C., Moreira de Souza, L.H., Yue, X., Ikegami, D., Moutal, A., Patwardhan, A., Khanna, R., Yamazaki, M., Guerrero, M., Rosen, H., Roberts, E., Neugebauer, V., Dodick, D.W., Porreca, F. Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signaling to promote wakefulness and vigilance. Brain 153, 2022. PMID: 35485490.

• Yakhnitsa, V., Ji, G., Hein, M., Presto, P., Griffin, Z., Ponomareva, I., Navratilova, E., Porreca, F., Neugebauer, V. Kappa opioid receptor blockade in the amygdala mitigates pain like-behaviors by inhibiting CRF neurons in a rat model of functional pain. Front. Pharmacol. 13: 903978 (16 pp.), 2022. PMID: 35694266. PMC9177060.

• Presto, P., Neugebauer, V. Sex differences in CGRP regulation and function in the amygdala in a rat model of neuropathic pain. Front. Mol. Neurosci. 15:928587 (14pp.), 2022. PMID:35726298. PMC9206543

• D. Appiah, G. Ashworth, A. Boles, et al.  The Association of Heart/Vascular Aging with Mild Cognitive Impairment in a Rural Multiethnic Cohort:  The Project FRONTIER Study. J Prev Alz Dis 2022; http://dx.doi.org/10.14283/jpad.2022.15 

• Awasthi S., Hindle A., Sawant N.A., George M., Vijayan M., Kshirsagar S., Morton H., Bunquin L.E., Palade P.T., Lawrence J.J., Khan H., Bose C., Reddy P.H., Singh S.P. RALBP1in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease. Cells. 10:3113, 2021. PMID: 34831336

• Freese K.E., Vega A., Lawrence J.J., Documet P.I., Social Vulnerability Is Associated with Risk of COVID-19 Related Mortality in U.S. Counties with Confirmed Cases. J Health Care Poor Underserved 32:245-257, 2021 PMID: 33678695

• Avila, M., Neugebauer, V., DeToledo, J. Gender differences in MS related pain, correlation with MRI lesion localization and burden of disease. Pharm. Pharmacol. Int. J. 9:258‒261, 2021.

• Ashraf-Uz-Zaman, M., Ji, G., Tidwell, D., Yin, L., Thakolwiboon, S., Neugebauer, V., Pan, J., Shahi, S., Sajib, M.S., Trippier, P., Mikelis, C., Avila, M., German, N., Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalo: myelitis Model of Multiple Sclerosis. ACS Chemical Neuroscience (accepted), 2021.

• Shen, C.-L., Watkins, B., Kahathuduwa, C., Chyu, M.-C., Zabet, M., Elmassry, M.M., Luk, H.-Y., Brismee, J.-M., Knox, A., Lee, J., Zumwalt, M., Wang, R., Wager, T.D., Neugebauer, V. Tai Chi improves brain functional connectivity and plasma lysophosphatidylcholines in postmenopausal women with knee osteoarthritis: an exploratory pilot study. Front. Med. 8: 775344, 2021.

• Shen, C.-L., Wang, R., Ji, G., Elmassry, M.M., Zabet-Moghaddam, M., Vellers, H., Hamood, A.N., Gong, X., Mirzaei, P., Sang, S., Neugebauer, V. Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation. J. Nutr. Biochem. 100: 108904, 2021. PMID: 34748918

• Mazzitelli, M., Neugebauer V. mGlu3 – New hope for pharmacotherapy of schizophrenia. Biol. Psychiatry 90 356–358, 2021. PMID: 34446153

• Presto, P., Ji, G., Junell, R., Griffin, Z., Neugebauer, V. Fear extinction based inter-individual and sex differences in pain-related vocalizations and anxiety-like behaviors but not nocifensive reflexes. Brain Sci. 11: 1339 (19 pp.), 2021. PMID: 34679403. PMC8533751.

• Gandhi, P.J., Gawande, D.Y., Shelkar, G.P., Gakare, S.G., Kiritoshi, T., Ji, G., Misra, B., Pavuluri, R., Liu, J., Neugebauer, V., Dravid, S. Dysfunction of glutamate delta-1 receptor-cerebellin 1 trans-synaptic signaling in the central amygdala in chronic pain. Cells 10: 2644 (25 pages), 2021.

• Hein, M., Ji, G., Tidwell, D., D’Souza, P., Kiritoshi, T., Yakhnitsa, V., Navratilova, E., Porreca, F., Neugebauer, V. Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors. Neuropharmacology 185: 108456 (13 pp.), 2021. PMID: 33444637. PMC7887082.

• Mazzitelli, M., Marshall, K., Pham, A., Ji, G., Neugebauer, V. Optogenetic manipulations of amygdala neurons modulate spinal nociceptive processing and behavior under normal conditions and in an arthritis pain model. Front. Pharmacol. 12: 668337 (18 pp.), 2021. PMID: 34113253. PMC8185300.

• Yi F, Garrett T, Deisseroth K, Haario H, Stone E, Lawrence JJ. Septo-hippocampal transmission from parvalbumin-positive neurons features rapid recovery from synaptic depression. Sci Rep. 11:2117, 2021. PMID: 33483520

• Navratilova, E., Nation, K., Remeniuk, B., Neugebauer, V., Bannister, K., Dickenson, A.H., Porreca, F. Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the right central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex. Pain: 161:609-618, 2020. PMID: 31725062. PMC7124010 [Featured Article: Editor’s Choice].

• Navratilova, E., Nation, K., Remeniuk, B., Neugebauer, V., Bannister, K., Dickenson, A.H., Porreca, F. Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the right central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex. Pain: 161:609-618, 2020. PMID: 31725062.[Featured Article: Editor’s Choice].

• Chen, Y., Moutal, A., Navratilova, E., Kopruszinski, C., Yue, X., Ikegami, M., Chow, M., Kanazawa, I., Bellampalli, S.S., Xie, J., Patwardhan, A., Rice, K., Fields, H., Akopian, A., Neugebauer, V., Dodick, D., Khanna, R., Porreca, F. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. Sci. Translat. Med. 12:529 eaay7550, DOI: 10.1126/scitranslmed.aay7550, 2020. PMID: 32024801. PMC7523341 [Evaluated in F1000 Faculty Opinions by I. Vetter and R. Ji, https://f1000.com/prime/737321616].

• Chen, Y., Moutal, A., Navratilova, E., Kopruszinski, C., Yue, X., Ikegami, M., Chow, M., Kanazawa, I., Bellampalli, S.S., Xie, J., Patwardhan, A., Rice, K., Fields, H., Akopian, A., Neugebauer, V., Dodick, D., Khanna, R., Porreca, F. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. Sci Translat Med 12:529 eaay7550, DOI: 10.1126/scitranslmed.aay7550, 2020. PMID: 32024801.

• Sekulić V, Yi F, Garrett T, Guet-McCreight A, Lawrence JJ, Skinner FK. Integration of Within-Cell Experimental Data With Multi-Compartmental Modeling Predicts H-Channel Densities and Distributions in Hippocampal OLM Cells. Front Cell Neurosci. 2020 Sep 17;14:277. PMID: 33093823

• Ji, G. and Neugebauer, V. Kappa opioid receptors in the central amygdala modulate spinal nociceptive processing through an action on amygdala CRF neurons. Mol. Brain 13: 128 (10 pp), 2020. PMID: 32948219. PMC7501648

• Neugebauer, V. Serotonin – Pain Modulation. In: Mueller, C.P., Cunningham, K.A. (Eds.) Handbook of the Behavioral Neurobiology of Serotonin, 2nd Edition, Handbook of Behavioral Neurosciences, 31: 309-320, 2020. ISBN: 9780444641250.

• Neugebauer, V. Amygdala Physiology in Pain. In: Rosenkranz, J.A., Urban, J.H. (Eds.) Handbook of Amygdala Structure and Function, Handbook of Behavioral Neurosciences, 26: 101-113, 2020. ISBN: 9780128151341.

• Neugebauer, V., Mazzitelli, M., Cragg, B., Ji, G., Navratilova, E., Porreca, F. Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology 170: 108052 (13 pp), 2020. PMID: 32188569. PMC7214122.

• Thompson, J.M., Neugebauer, V. Cortico-limbic pain mechanisms. Neurosci. Lett. 702:15-23, 2019. PMID 30503916. PMC6520155.

• Boccella, S, Marabese, I, Iannotta, M, Belardo, C, Neugebauer, V, Mazzitelli, M, Pieretti, G, Maione, S, Palazzo, E. Metabotropic glutamate receptor 5 and 8 modulate the ameliorative effect of ultramicronized palmitoylethanolamide on cognitive decline associated with neuropathic pain. Int J Mol Sci 20:1757, 2019.

• Palazzo, E, Neugebauer, V, Maione, S. Metabotropic glutamate receptors and neurological/psychiatric disorders. Front Mol Neurosci 12:67-68, 2019.

• Navratilova, E., Ji, G., Phelps, C.E., Qu, C., Hein, M., Yakhnitsa, V., Neugebauer, V., Porreca, F. Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain. Pain 160:824–832, 2019. PMID 30681985.

• Mazzitelli, M., Neugebauer, V. Amygdala group II mGluRs mediate the antinociceptive effects of a systemic group II agonist in a rodent model of arthritis pain. Neuropharmacology 158:107706, 2019. PMID: 31306647. PMC6745268

• Ji, G. and Neugebauer, V. Contribution of CRF1 receptor to 5-HT2C receptor function in amygdala neurons in a neuropathic pain model. Int. J. Mol. Sci. 20:4380. 2019. PMID: 31489921.