Mass Spectrometry Core Publications

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Publications - Mass Spectrometry Core

Evaluation of Systemic and Brain Pharmacokinetic Parameters for Repurposing Metformin Using Intravenous Bolus Administration Sharma, S., Zhang, Y., Patel, D., Akter, K. A., Bagchi, S., Sifat, A. E., Nozohouri, E., Ahn, Y., Karamyan, V. T., Bickel, U., & Abbruscato, T. J. (2024).. J Pharmacol Exp Ther.
Characterization of a Nonselective Opioid Receptor Functional Antagonist: Implications for Development as a Novel Opioid Dependence Medication. Shahbazi Nia, S., Ortiz, Y. T., Zuarth Gonzalez, J. D., Shamir, L., Frimpong-Manson, K., Hossain, M. A., Shahi, S., Bandy, R., Bhat, A., Patel, D., Diab, H., Thompson, J., McMahon, L. R., Wilkerson, J. L., & German, N. A. (2024). ACS Pharmacol Transl Sci, 7(3), 654-666
Higher Brain Uptake of Gentamicin and Ceftazidime under Isoflurane Anesthesia Compared to Ketamine/Xylazine. Ahn, Y., Patil, C. D., Nozohouri, E., Zoubi, S., Patel, D., & Bickel, U. (2024). Pharmaceutics, 16(1).

Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals. Zhang, Y., Sharma, S., Jonnalagadda, S., Kumari, S., Queen, A., Esfahani, S. H., Archie, S. R., Nozohouri, S., Patel, D., Trippier, P. C., Karamyan, V. T., & Abbruscato, T. J. (2023)Pharm Res, 40(11), 2747-2758.
Ketone bodies supplementation restores the barrier function, induces a metabolic switch, and elicits beta-hydroxybutyrate diffusion across a monolayer of iPSC-derived brain microvascular endothelial cells. Pervaiz, I., Mehta, Y., Sherill, K., Patel, D., & Al-Ahmad, A. J. (2023). Microvasc Res, 150, 104585.
Systemic and Brain Pharmacokinetics of Milnacipran in Mice: Comparison of Intraperitoneal and Intravenous Administration. Bagchi, S., Nozohouri, E., Ahn, Y., Patel, D., Bickel, U., & Karamyan, V. T. (2023). Pharmaceutics, 16(1).
Permeability of Metformin across an In Vitro Blood-Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters. (Octs), Sharma, S., Y. Zhang, K.A. Akter, S. Nozohouri, S.R. Archie, D. Patel, H. Villalba, and T. Abbruscato, Pharmaceutics, 2023. 15(5).
Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands. Shahbazi Nia, S., M.A. Hossain, G. Ji, S.K. Jonnalagadda, S. Obeng, M.A. Rahman, A.E. Sifat, S. Nozohouri, C. Blackwell, D. Patel, J. Thompson, S. Runyon, T. Hiranita, C.R. McCurdy, L. McMahon, T.J. Abbruscato, P.C. Trippier, V. Neugebauer, and N.A. German,Eur J Med Chem, 2023. 254: p. 115309.
Effects of Volatile Anesthetics versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes. Noorani, B., E.A. Chowdhury, F. Alqahtani, Y. Ahn, E. Nozohouri, S. Zoubi, D. Patel, L. Wood, J. Huang, M.B. Siddique, A. Al-Ahmad, R. Mehvar, and U. Bickel,J
Endothelial-Specific Targeting of RhoA Signaling via CD31 Antibody-Conjugated Nanoparticles. Lahooti, B., R.G. Akwii, D. Patel, S. ShahbaziNia, M. Lamprou, M. Madadi, T.J. Abbruscato, A. Astrinidis, U. Bickel, A. Al-Ahmad, N.A. German, G. Mattheolabakis, and C.M. Mikelis,J Pharmacol Exp Ther, 2023. 385(1): p. 35-49.
Validation of an LC-MS/MS method for assessment of fenbendazole sulfone drug residue in northern bobwhite liver. Henry, B.J., D. Patel, C. Henry, M.Z. Brym, and R.J. Kendall,Biomed Chromatogr, 2023: p. e5637.
In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals. Nozohouri, S., S.H. Esfahani, B. Noorani, D. Patel, H. Villalba, Y. Ghanwatkar, M.S. Rahman, Y. Zhang, U. Bickel, P.C. Trippier, V.T. Karamyan, and T.J. Abbruscato,Pharm Res, 2022. 39(7): p. 1587-1598.

Antibody-drug Conjugate PCMC1D3-Duocarmycin SA as a Novel Therapeutic Entity for Targeted Treatment of Cancers Aberrantly Expressing MET Receptor Tyrosine Kinase. Hudson, Rachel; Yao, Hang-Ping; Suthe, Sreedhar R.; Patel, Dhavalkumar; Wang, Ming-Hai, Current Cancer Drug Targets, Volume 22, Number 4, 2022, pp. 312-327(16) DOI: https://doi.org/10.2174/1568009621666211222154129.
Pharmacokinetics of a single dose of oclacitinib maleate as a top dress in adult horses. Hunyadi, L., Datta, P., Rewers-Felkins, K., Sundman, E., Hale, T., Fajt, V., & Wagner, S. (2022). Journal of Veterinary Pharmacology and Therapeutics, 45, 320– 324. https://doi.org/10.1111/jvp.13043
In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals. Pharm Res (2022). Nozohouri, S., Esfahani, S.H., Noorani, B. et al.
A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice. Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Md Sanaullah Sajib, Yeseul Ahn, Ehsan Nozohouri, Dhavalkumar Patel, Constantinos Mikelis, Reza Mehvar & Ulrich Bickel .Pharm Res 39, 251–261 (2022).
Effect of a very low negative dietary cation-anion difference (DCAD) diet on plasma and urine metabolomics of prepartum Holstein cows. P. Melendez, P.K. Chelikani, D. Patel, E. Garbarino, JDS Communications, Volume 3, Issue 1, 2022, Pages 59-65, ISSN 2666-9102, https://doi.org/10.3168/jdsc.2021-0154
Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability. [published correction appears in J Med Chem. 2022 Jan 13;65(1):890]. Rahman MS, Kumari S, Esfahani SH, et al. J Med Chem. 2021;64(17):12705-12722. doi:10.1021/acs.jmedchem.1c00759
Prenatal E-Cigarette Use Disrupts Blood-Brain Barrier (BBB) Integrity and Induces Pro-Inflammatory Cytokines in Postnatal Brain. Rahman Archie, S., Sifat, A.E., Villalba, H., Sharma, S., Nozohouri, S., Zhang, Y. and Abbruscato, T. (2022),The FASEB Journal, 36:.

Human Milk Endocannabinoid Levels as a Function of Obesity and Diurnal Rhythm. Datta, Palika, Michael W. Melkus, Kathleen Rewers-Felkins, Dhavalkumar Patel, Tiffany Bateman, Teresa Baker, and Thomas W. Hale. 2021. Nutrients 13, no. 7: 2297.
Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers. Kadry, H., Noorani, B., Bickel, U. et al. Fluids Barriers CNS 18, 28 (2021). https://doi.org/10.1186/s12987-021-00261-4
A Quasi-Physiological Microfluidic Blood-Brain Barrier Model for Brain Permeability Studies. Noorani B, Bhalerao A, Raut S, Nozohouri E, Bickel U, Cucullo L. Pharmaceutics 2021; 13(9):1474.

LC-MS/MS-based in vitro and in vivo investigation of blood-brain barrier integrity by simultaneous quantitation of mannitol and sucrose. Noorani B, Chowdhury EA, Alqahtani F, Ahn Y, Patel D, Al-Ahmad A, Mehvar R, Bickel U. Fluids Barriers CNS. 2020 Oct 14;17(1):61. doi: 10.1186/s12987-020-00224-1. PMID: 33054801; PMCID: PMC7556948.1.
Maternal Transfer of Cetirizine Into Human Milk [published online ahead of print, 2020 Aug 27]. Wilkerson H, Datta P, Rewers-Felkins K, Baker T, Hale TW. J Hum Lact. 2020;890334420949847. doi:10.1177/08903344209498471.
Cladribine transfer into human milk: A case report [published online ahead of print, 2020 Jun 8]. Datta P, Ciplea AI, Rewers-Felkins K, et al. Mult Scler. 2020;1352458520912173. doi:10.1177/1352458520912173
Rivaroxaban Treatment in Two Breastfeeding Mothers: A Case Series. Muysson M, Marshall K, Datta P, Rewers-Felkins K, Baker T, Hale TW.Breastfeed Med. 2020;15(1):41-43. doi:10.1089/bfm.2019.0124

Determination of Mesalamine levels in Human Milk as a Function of Dose. Breastfeed Med. Datta P, Rewers-Felkins K, Kallem RR, Baker T, Hale TW.2019;14(2):98-101. doi:10.1089/bfm.2018.0111
CAR, a Homing Peptide, Prolongs Pulmonary Preferential Vasodilation by Increasing Pulmonary Retention and Reducing Systemic Absorption of Liposomal Fasudil. Keshavarz A, Alobaida A, McMurtry IF, Nozik-Grayck E, Stenmark KR, Ahsan F.Mol Pharm. 2019;16(8):3414-3429. doi:10.1021/acs.molpharmaceut.9b00208
Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging. Punganuru SR, Madala HR, Arutla V, Zhang R, Srivenugopal KS.Sci Rep. 2019;9(1):8577. Published 2019 Jun 12. doi:10.1038/s41598-019-44111-8
Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP). Albekairi TH, Vaidya B, Patel R, Nozohouri S, Villalba H, Zhang Y, et al. Pharmaceutics. 2019;11(9).
Cyclophosphamide Use in Multiple Sclerosis: Levels Detected in Human Milk. Fierro ME, Datta P, Rewers-Felkins K, et al. Breastfeed Med. 2019;14(2):128-130. doi:10.1089/bfm.2018.0137

Gliotoxin penetrates and impairs the integrity of the human blood-brain barrier in vitro. Patel R, Hossain MA, German N, Al-Ahmad AJ. Mycotoxin Res. 2018;34(4):257-268. doi:10.1007/s12550-018-0320-7
Effect of maternal high-fat diet on key components of the placental and hepatic endocannabinoid system. Gandhi K, Li C, German N, et al. Am J Physiol Endocrinol Metab. 2018;314(4):E322-E333. doi:10.1152/ajpendo.00119.2017
Transfer of Inhaled Cannabis Into Human Breast Milk. Baker T, Datta P, Rewers-Felkins K, Thompson H, Kallem RR, Hale TW. Obstet Gynecol. 2018;131(5):783-788. doi:10.1097/AOG.0000000000002575.
Selective killing of human breast cancer cells by the styryl lactone (R)-goniothalamin is mediated by glutathione conjugation, induction of oxidative stress and marked reactivation of the R175H mutant p53 protein. Punganuru SR, Madala HR, Arutla V, Srivenugopal KS. Carcinogenesis. 2018;39(11):1399-410
Simultaneous UPLC-MS/MS analysis of two stable isotope labeled versions of sucrose in mouse plasma and brain samples as markers of blood-brain barrier permeability and brain vascular space. Chowdhury EA, Alqahtani F, Bhattacharya R, Mehvar R, Bickel U. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1073:19-26.
Brain Uptake of [(13)C] and [(14)C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice. Alqahtani F, Chowdhury EA, Bhattacharya R, Noorani B, Mehvar R, Bickel U. Drug Metab Dispos. 2018;46(11):1514-8.

Transfer of Low Dose Aspirin Into Human Milk. Datta P, Rewers-Felkins K, Kallem RR, Baker T, Hale TW. J Hum Lact. 2017;33(2):296-299. doi:10.1177/0890334417695207
Transfer of Montelukast into Human Milk During Lactation. Breastfeed Med. Datta P, Rewers-Felkins K, Baker T, Hale TW. 2017;12:54-57. doi:10.1089/bfm.2016.0162.
Evaluation of [(14)C] and [(13)C]Sucrose as Blood-Brain Barrier Permeability Markers. Miah MK, Chowdhury EA, Bickel U, Mehvar R. J Pharm Sci. 2017;106(6):1659-69.
A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse. Kaisar MA, Kallem RR, Sajja RK, Sifat AE, Cucullo L. BMC Neurosci. 2017;18(1):71

Preparation and preliminary characterization of recombinant neurolysin for in vivo studies. Wangler NJ, Jayaraman S, Zhu R, Mechref Y, Abbruscato TJ, Bickel U, et al. J Biotechnol. 2016;234:105-15.
Rashid J, Ahsan F. A highly sensitive LC-MS/MS method for concurrent determination of sildenafil and rosiglitazone in rat plasma. Rashid J, Ahsan F. J Pharm Biomed Anal. 2016;129:21-7.
Development and validation of a sensitive UPLC-MS/MS method for the quantitation of [(13)C]sucrose in rat plasma, blood, and brain: Its application to the measurement of blood-brain barrier permeability. Miah MK, Bickel U, Mehvar R. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1015-1016:105-10.
Short Stereoselective synthesis of (+)-Monocerin via a Palladium-Catalysed Intramolecular Alkoxycarbonylation. Punganuru SR, Aviraboina S, Srivenugopal KS. Journal of Chemical Research. 2016;40(6):375-378. doi:10.3184/174751916X14636665341699
Nanoemulsion formulations for anti-cancer agent piplartine--Characterization, toxicological, pharmacokinetics and efficacy studies. Fofaria NM, Qhattal HS, Liu X, Srivastava SK. Int J Pharm. 2016;498(1-2):12-22.
Pyranocoumarin Tissue Distribution, Plasma Metabolome and Prostate Transcriptome Impacts of Sub-Chronic Exposure to Korean Angelica Supplement in Mice. Zhang J, Li L, Tang S, et al. Am J Chin Med. 2016;44(2):321-353. doi:10.1142/S0192415X16500191