Center for Tumor Immunology and Targeted Cancer Therapy
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Center for Tumor Immunology and Targeted Cancer Therapy
Mission:
The mission of the Center is to improve cancer patient care through the development and implementation of novel immunotherapies and targeted therapies for cancer.
Vision:
To grow basic, translational, and clinical research in tumor immunology, cancer biology and personalized medicine at the School of Pharmacy through the establishment of a team of multidisciplinary and interdepartmental investigators working in a highly collaborative and supportive environment.
Analytical Instrumentation:
A flagship confocal microscope with integrated AI for peak combination of image area, resolution, speed and sensitivity featuring largest field of view (25mm field of view {FOV}), in both resonant and galvano mode. Ultra-high-speed imaging up to 720 fps at 2048 x 16 resolution in resonant mode, stunning 8K X 8K high definition resolution in Galvano mode and Equipped with 4 lasers 405, 488, 561, and 640nm. and 4-channel ultra-high sensitivity DUX VB GaAsP detectors. Artificial intelligence algorithms such as Denoise.ai, remove Poisson shot noise from resonant scanned images, and increase signal-to-noise ratio, Auto-signal.ai suggests a best acquisition configuration to improve image quality and user efficiency.
Create high-quality digital slides with the ultra-compact Aperio CS2 image capture device – from your desktop. With a five-slide capacity and 20X and 40x magnification capabilities, the Aperio CS2 is a highly reliable workhorse for medium-volume sites.
Aperio CS2 is the ideal tool for preparing slides and data to be shared with other team members for collaboration. Remote assessment of digital slides can improve study turnaround time and ease of access for team members.
A compact, small footprint, high image quality whole slide line scanning instrument, Aperio CS2 occupies only 1.6 square feet of bench top space.
The BD LSRFortessa™ cell analyzer offers the ultimate choice for flow cytometry, providing power, performance, and consistency. Designed to be affordable and expandable, the BD LSRFortessa has the flexibility to support the expanding needs of multicolor flow cytometry assays. The BD LSRFortessa analyzer is configured with up to 3 lasers—blue, red, and violet- which simultaneously enables the detection of up to 13 colors. The BD LSR Fortessa may be upgraded subsequently with additional or new lasers from BD, as future requirements dictate.
The BD FACSAria cell sorter sets a new standard for high-performance flow cytometry. Based on an entirely new instrumentation design, the BD FACSAria instrument is the first benchtop sorter that incorporates a fixed-alignment cuvette flow cell. The numerous technological advances embodied in the BD FACSAria cell sorter reduce the cost of owning a high-speed sorter and accelerate research by providing unparalleled, easy-to-use, high-performance sorting and analysis.
The BD FACS Aria sorter is configured with 2 lasers—blue and red - which simultaneously enables the detection of up to 7 colors and can be upgrade for 3lasers.
RS 2000 specializes in providing non-isotope, ionizing irradiation. Ionizing radiation that is similar to the radioactive sources, cobalt-60 and cesium-137. RS 2000 utilizes Rad Source’s X-ray tube technology and RAD+ reflector to generate an efficient and uniform X-ray ionizing radiation field, to provide excellent irradiation effect, and good repeatability.
IVIS from Perkin Elmer offers single-view 3D tomography for both fluorescent and bioluminescent reporters and has capability to illuminate either trans-illumination (from the bottom) or epi-illumination (from the top) fluorescent sources that can be analyzed in an anatomical context.
3D diffuse fluorescence tomography can be performed to determine source localization and concentration using the combination of structured light and trans-illumination fluorescent images.
Center Members:
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Maciej Markiewski, M.D., Ph.D.
Center Director, Professor
Department of Immunotherapeutics and Biotechnology
Maciej.Markiewski@ttuhs.edu
Focus of Research: Tumor immunology, complement biology, pathology
Complete list of published work:
https://www.ncbi.nlm.nih.gov/myncbi/maciej.markiewski.1/bibliography/public/
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Magdalena Karbowniczek, M.D., Ph.D.
Professor
Department of Immunotherapeutics and Biotechnology
Magdalena.Karbowniczek@ttuhsc.edu
Focus of Research: Cancer biology, pulmonary lymphangioleiomyomatosis, extracellular vessicles
Complete list of published work in:
https://www.ncbi.nlm.nih.gov/sites/myncbi/magdalena.karbowniczek.1/bibliography/47391208/public/
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Ninh "Irene" La-Beck, Pharm.D.
Associate Professor
Department of Immunotherapeutics and Biotechnology
Irene.La-Beck@ttuhsc.edu
Focus of Research: Drug delivery systems, nanotechnology, tumor immunology
Complete list of published work:
https://www.ncbi.nlm.nih.gov/myncbi/ninh.la-beck.1/bibliography/public/
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Devin Lowe, Ph.D.
Associate Professor
Department of Immunotherapeutics and Biotechnology
Devin.Lowe@ttuhsc.edu
Focus of Research: Tumor immunology, cancer immunotherapy
Complete list of published work:
To view click here.
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Sanjay K. Srivastava, Ph.D.
Professor and Chair
Department of Immunotherapeutics and Biotechnology
Sanjay.Srivastava@ttuhsc.edu
Focus of Research: Cancer biology, drug repurposing, drug resistance, experimental therapeutics, and molecular pharmacology
Complete list of published work:
https://www.ncbi.nlm.nih.gov/myncbi/sanjay.srivastava.2/bibliography/public/
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Todd Triplett, Ph.D.
Assistant Professor
Department of Immunotherapeutics and Biotechnology
Todd.Triplett@ttuhsc.edu
Focus of Research: T cell biology, tumor immunology, cancer immunotherpy
Complete list of published work:
https://www.ncbi.nlm.nih.gov/myncbi/todd.triplett.1/bibliography/public/
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Laurence Wood, Ph.D.
Associate Professor
Department of Immunotherapeutics and Biotechnology
Laurence.Wood@ttuhsc.edu
Focus of Research: Tumor immunology, listeria monocytogenes anticancer vaccines
Complete list of published work:
https://www.ncbi.nlm.nih.gov/myncbi/1nesmlew2iB5j/bibliography/public/
Got Questions?
We're here to help. Contact us if you have questions.
Maciej Markiewski, M.D., Ph.D.
Center Director
Maciej.Markiewski@ttuhsc.edu
325.696.0430
1718 Pine St.
Abilene, TX 79601