Ulrich Bickel Laboratory
About Us
information about the lab
Research Interest
The Team
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Yeseul Ahn Graduate Student/ Research Assistant |
Ehsan Nozohouri Graduate Student/ Research Assistant |
Dhaval Patel Graduate Student / Research Assistant |
Sumaih Zoubi Graduate Student / Research Assistant |
- US20140134241 A1 - WO2012129520A1 - TCR Mimic Antibodies as Vascular Targeting Tools (John Weidanz & Ulrich Bickel)
- Bickel U. Modeling Blood–Brain Barrier Permeability to Solutes and Drugs In Vivo. Pharmaceutics. 2022; 14(8):1696. https://doi.org/10.3390/pharmaceutics14081696
- Nozohouri S, Esfahani SH, Noorani B, et al. In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals. Pharm Res. 2022;39(7):1587-1598. doi:10.1007/s11095-022-03218-w
- Noorani B, Chowdhury EA, Alqahtani F, et al. A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice. Pharm Res. 2022;39(2):251-261. doi:10.1007/s11095-022-03175-4
- Noorani B, Bhalerao A, Raut S, Nozohouri E, Bickel U, Cucullo L. A Quasi-Physiological Microfluidic Blood-Brain Barrier Model for Brain Permeability Studies. Pharmaceutics. 2021;13(9):1474. Published 2021 Sep 15. doi:10.3390/pharmaceutics13091474
- Kadry H, Noorani B, Bickel U, Abbruscato TJ, Cucullo L. Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers. Fluids Barriers CNS. 2021;18(1):28. Published 2021 Jun 22. doi:10.1186/s12987-021-00261-4
- Koopaei NN, Chowdhury EA, Jiang J, et al. Enrichment of the erythrocyte miR-451a in brain extracellular vesicles following impairment of the blood-brain barrier. Neurosci Lett. 2021;751:135829. doi:10.1016/j.neulet.2021.135829
- Noorani B, Chowdhury EA, Alqahtani F, et al. LC-MS/MS-based in vitro and in vivo investigation of blood-brain barrier integrity by simultaneous quantitation of mannitol and sucrose. Fluids Barriers CNS. 2020;17(1):61. Published 2020 Oct 14. doi:10.1186/s12987-020-00224-1
- Patel J, Chowdhury EA, Noorani B, Bickel U, Huang J. Isoflurane increases cell membrane fluidity significantly at clinical concentrations. Biochimica et biophysica acta. Biomembranes. 2020;1862(2):183140.
- Alqahtani F, Chowdhury EA, Bhattacharya R, Noorani B, Mehvar R, Bickel U. Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice. Drug metabolism and disposition: the biological fate of chemicals. 2018;46(11):1514-1518.
- Chowdhury EA, Alqahtani F, Bhattacharya R, Mehvar R, Bickel U. Simultaneous UPLC-MS/MS analysis of two stable isotope labeled versions of sucrose in mouse plasma and brain samples as markers of blood-brain barrier permeability and brain vascular space. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018;1073:19-26.
- Miah MK, Bickel U, Mehvar R. Effects of hepatic ischemia-reperfusion injury on the blood-brain barrier permeability to [14C] and [13C]sucrose. Metabolic brain disease. 2017;32(6):1903-1912.
- Miah MK, Chowdhury EA, Bickel U, Mehvar R. Evaluation of [14C] and [13C]Sucrose as Blood-Brain Barrier Permeability Markers. Journal of pharmaceutical sciences. 2017;106(6):1659-1669.
- Wangler NJ, Jayaraman S, Zhu R, Mechref Y, Abbruscato TJ, Bickel U, Karamyan VT. Preparation and preliminary characterization of recombinant neurolysin for in vivo studies. Journal of biotechnology. 2016;234:105-115.
- Miah MK, Bickel U, Mehvar R. Development and validation of a sensitive UPLC-MS/MS method for the quantitation of [(13)C]sucrose in rat plasma, blood, and brain: Its application to the measurement of blood-brain barrier permeability. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016;1015-1016:105-110.
- Miah MK, Shaik IH, Bickel U, Mehvar R. Effects of Pringle maneuver and partial hepatectomy on the pharmacokinetics and blood-brain barrier permeability of sodium fluorescein in rats. Brain research. 2015;1618:249-60.
- Shaik IH, Miah MK, Bickel U, Mehvar R. Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats. Brain research. 2013;1531:84-93.
- Miah MK, Shaik IH, Bickel U, Mehvar R. Effects of hepatic ischemia-reperfusion injury
on the P-glycoprotein activity at the liver canalicular membrane and blood-brain barrier
determined by in vivo administration of rhodamine 123 in rats. Pharmaceutical research.
2014;31(4):861-73.
Hao J, Bickel U. Transferrin receptor mediated brain uptake during ischemia and reperfusion. J Pharm Pharm Sci. 2011;16(4):541-550.
Updated: 10/11/2022
Contact Us:
Ulrich Bickel, M.D.
Associate Dean, Office of Sciences
Associate Professor, Department of Pharmaceutical Sciences
(806) 414-9236
Office: ARB 2101 & SOP 446
Lab: SOP B37
Texas Tech University Health Sciences Center
School of Pharmacy
1406 S. Coulter St
Amarillo, TX, USA, 79106
Funding:
