Dr. Boris Decourt Faculty Page

Research Activities

Dr. Boris Decourt is an Assistant Professor at TTUHSC, School of Medicine. He is the Director of the Laboratory on Neurodegeneration and Translational Research. Our laboratory focuses on three main lines of research:

1. We carry out pharmacological experiments on several models of Alzheimer's disease (AD), including cell cultures and rodents (transgenic mice). We also conduct molecular and protein analyses to investigate the phenotypes of our models with and without drug challenge. 
   
   
2. We are involved in several AD clinical trials (2 are funded by the NIH on one funded by a private foundation) and carry out biomarker development experiments for neurodegenerative disorders on human biofluids.
   
   
3. We participate in community-based dementia research activities in rural areas around Lubbock, Texas. We also have collaborations with local clinicians to initiate pilot projects aimed at improving the medical care provided to residents in the community we serve. 

Dr. Decourt is a member of the TTUHSC Garrison Institute on aging (GIA), which manages the Project FRONTIER (Facing Rural Obstacles to Healthcare Now Through Intervention, Education and Research) study in West Texas, and a member of the Steering Committee for the TTUHSC Center of Excellence for Translational Neuroscience and Therapeutics (CTNT)

Major Publications

• Majeed J, Sabbagh MN, Kang MH, Lawrence JJ, Pruitt K, Bacus S, Reyna E, Brown M, Decourt B. (2023) “Cancer drugs with high repositioning potential for Alzheimer's disease.” Expert Opinion on Emerging Drugs [PMID: 38100555]
• Decourt B., D’Souza G., Shi J., Ritter M., Suazo, J., Sabbagh M.N. (2022) "The Cause of Alzheimer’s Disease: The Theory of Multipathology Convergence to Chronic Neuronal Stress." Aging and Disease [PMID: 35111361]
• Sabbagh MN, Decourt B. (2023) "Biomarker-based diagnosis of preclinical Alzheimer disease: time for the clinic?" Nature Reviews Neurology [PMID: 36627511]
• Decourt B., Sabbagh MN (2022) "The importance of genomics in advancing the diagnosis and treatment of dementia." Lancet Neurology [PMID: 35697056]

Full list of publications can be found here