Murali Vijayan

I am a dedicated researcher with a background in mitochondrial biology, microRNA (miRNA) biology, and genetics.  My academic journey began in 2010 with a Ph.D. from Bharathidasan University, where I investigated the genetic underpinnings of stroke, aiming to unravel its complex etiology.

Following this, in November 2015, I transitioned into a postdoctoral position at Dr. Reddy's lab, focusing on elucidating miRNA regulation in ischemic stroke.  This research yielded significant outcomes, including the acquisition of a U.S. patent and publication of impactful findings.

Building upon this foundation, I advanced to the role of Research Assistant Professor in 2021.  In this capacity, I expanded my research scope to encompass small molecule interventions in Alzheimer's disease (AD), targeting the role of voltage-dependent anion channel 1 (VDAC1)-an intersection of my expertise in molecular mechanisms and neurodegenerative disorders.  During this tenure, I engaged in several research projects, notably characterizing Alzheimer's disease mouse models (P301L) and conducting genetic crossings with VDAC1 heterozygote knockout mice (VDAC1+/-) to explore the protective effects of reduced VDAC1 in Tau mice.   Additionally, I managed various mouse lines and performed cognitive behavior assessments using rotarod, Morris Water Maze, open field, and Y-maze tests.

Furthermore, my worked involved studying molecular inhibitors to reduce Aß and tau levels and inhibit abnormal protein interactions, alongside investigating the protective effects of soluble molecular inhibitors on APP and Tau transgenic mice.  These studies culminated in publications in esteemed journals, including Aging Cell, International Journal of Molecular Sciences, Human Molecular Genetics, Cells, and Molecular Neurobiology.

Throughout my academic and professional journey, I have been committed to advancing scientific knowledge and translating discoveries into tangible outcomes for patient care and therapeutic development.  My career trajectory reflects a passion for bridging fundamental research with clinical applications, aiming to contribute meaningfully to the understanding and treatment of neurological disorders.

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