Jaganathan Subramani, PhD | Texas Tech University Health Sciences Center

Jaganathan Subramani, PhD

Jaganathan Subramani

Jaganathan Subramani, PhD

Research Assistant Professor, Department of Internal Medicine

Curriculum Vitae

 

 

 
  • Subramani, J., Rezaul, K., Han, DK., and Shapiro LH.  CD13 phosphorylation and cytoskeletal anchors in monocyte adhesion. North American Vascular Biology Association (NAVBO) Workshops in Vascular Biology, October 16-20, Cape Cod, 2011, Poster no. 162.
  • Ghosh, M., McAuliffe, B., Subramani, J., Basu, S., Shapiro, L.H. CD13 regulates mannose receptor-mediated antigen uptake by dendritic cells. NAVBO Workshops in Vascular Biology, October 16-20, Cape Cod, 2011, Poster no. 157.
  • Ghosh, M., McAuliffe, B., Subramani, J., Basu, S. and Shapiro L. CD13 regulates dendritic cell cross presentation and T cell responses by inhibiting receptor mediated antigen uptake. Annual Meeting of the American Association of Immunologists. May 4-8, Boston, 2012, Abstract published in The Journal of Immunology, 188, 106.16.
  • Ghosh, M., Subramani J., Rahman M, Shapiro L. CD13 is a novel regulator of TLR4 endocytosis in dendritic cells (CAM5P. 241). Annual Meeting of the American Association of Immunologists. May 2-6, Pittsburgh, 2014, Abstract published in The Journal of Immunology 192 (1 Supplement), 180.12.
  • Ghosh, M., Subramani J., Rahman M, Shapiro L. CD13 restricts TLR4 endocytic signal transduction in inflammation (INM7P.350). Annual Meeting of The American Association of Immunologists, May 8-12, New Orleans, 2015, Abstract published in The Journal of Immunology, May 1, vol. 194 no. 1 Supplement 194.7.
  • Ghosh, M., Subramani J., Rahman M, Shapiro L. CD13 is a Novel Regulator of TLR4 Endocytosis in Dendritic Cells. Keystone Symposia March 3–8, 2013, Colorado | USA, Poster No. 3014.
  • Leo MD, Kandasamy K, Subramani J, Tandan SK, Kumar D. Involvement of inducible nitric oxide synthase and dimethylarginine dimethylaminohydrolase in Nω-Nitro-L-arginine methyl ester (L-NAME)-induced hypertension (LB676). Experimental biology meeting April 26-30, San Diego, 2014, Abstract published in The FASEB Journal (1 Supplement), 28, LB676.
  • Kundumani-Sridharan V, Van Quyen D, Subramani J, Singh NK, and Rao GN. Interaction between NFATc1 and STAT3 is required for thrombin-induced cyclin D1 expression in vascular smooth muscle cells. Experimental biology meeting, April 21-25, San Diego, 2012, Abstract published in The FASEB Journal, 26, 782.8.
 
  • Das KC, Kundumani-Sridharan V, Subramani J. Role of Thioredoxin in Age-Related Hypertension. (2018), Curr Hypertens Rep. Feb 14; 20(1):6.
  • Subramani J, Kundumani-Sridharan V, Hilgers RH, Owens C, Das KC. Thioredoxin Uses a GSH-independent Route to Deglutathionylate Endothelial Nitric-oxide Synthase and Protect against Myocardial Infarction. (2016), J Biol Chem. 291(45):23374-23389.
  • Hilgers RH, Kundumani-Sridharan V, Subramani J, Chen LC, Cuello LG, Rusch NJ, Das KC. Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function. (2017), Sci Transl Med., 9 (376).
  • Kundumani-Sridharan, V., Subramani, J., Das, K.C. Thioredoxin activates MKK4-NFκB pathway in a redox-dependent manner to control manganese superoxide dismutase gene expression in endothelial cells. (2015) Journal of Biological Chemistry, 290 (28), pp. 17505-17519.
  • Ghosh, M., Subramani, J., Rahman, M.M., Shapiro, L.H. CD13 restricts TLR4 endocytic signal transduction in inflammation. (2015) Journal of Immunology, 194 (9), pp. 4466-4476.
  • Leo, M.D., Kandasamy, K., Subramani, J., Tandan, S.K., Kumar, D. Involvement of inducible nitric oxide synthase and dimethyl arginine dimethylaminohydrolase in Nω-Nitro-L-arginine methyl ester (L-NAME)-induced hypertension. (2015) Cardiovascular Pathology, 24 (1), pp. 49-55.
  • Rahman, M.M., Subramani, J., Ghosh, M., Denninger, J.K., Takeda, K., Fong, G.-H., Carlson, M.E., Shapiro, L.H. CD13 promotes mesenchymal stem cell-mediated regeneration of ischemic muscle. (2014) Frontiers in Physiology, 4 JAN, art. No. 402,
  • Rahman, M.M., Ghosh, M., Subramani, J., Fong, G.-H., Carlson, M.E., Shapiro, L.H. CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury. (2014) Stem Cells, 32 (6), pp. 1564-1577.
  • Ghosh, M., Gerber, C., Rahman, M.M., Vernier, K.M., Pereira, F.E., Subramani, J., Caromile, L.A., Shapiro, L.H. Molecular mechanisms regulating CD13-mediated adhesion. (2014) Immunology, 142 (4), pp. 636-647.
  • Pereira, F.E., Cronin, C., Ghosh, M., Zhou, S.-Y., Agosto, M., Subramani, J., Wang, R., Shen, J.-B., Schacke, W., Liang, B., Yang, T.H., McAulliffe, B., Liang, B.T., Shapiro, L.H. CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice. (2013) Cardiovascular Research, 100 (1), pp. 74-83.
  • Subramani, J., Ghosh, M., Mamunur Rahman, M., Caromile, L.A., Gerber, C., Rezaul, K., Han, D.K., Shapiro, L.H. Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking. (2013) Journal of Immunology, 191 (7), pp. 3905-3912.
  • Kundumani-Sridharan, V., Van Quyen, D., Subramani, J., Singh, N.K., Chin, Y.E., Rao, G.N. Novel interactions between NFATc1 (nuclear factor of activated T cells c1) and STAT-3 (signal transducer and activator of transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation. (2012) Journal of Biological Chemistry, 287 (27), pp. 22463-22482.
  • Ghosh, M., McAuliffe, B., Subramani, J., Basu, S., Shapiro, L.H. CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake. (2012) Journal of Immunology, 188 (11), pp. 5489-5499.
  • Kundumani-Sridharan, V., Niu, J., Wang, D., Van Quyen, D., Zhang, Q., Singh, N.K., Subramani, J., Karri, S., Rao, G.N. 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression (2010) Blood, 115 (10), pp. 2105-2116.
  • Subramani, J., Leo, M.D.M., Kathirvel, K., Arunadevi, R., Singh, T.U., Prakash, V.R., Mishra, S.K. Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery. (2010) European Journal of Pharmacology, 630 (1-3), pp. 84-91.
  • Arunadevi, R., Ramteke, V.D., Kumar, S., Shukla, M.K., Subramani,J., Kumar, D., Sharma, A.K., Tandan, S.K. Neuroprotective effect of s-methylisothiourea in transient focal cerebral ischemia in rat. (2010) Nitric Oxide - Biology and Chemistry, 22 (1), pp. 1-10.
  • Subramani, J., Kathirvel, K., Leo, M.D.M., Kuntamallappanavar, G., Singh, T.U., Mishra, S.K. Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. (2009) Journal of Cardiovascular Pharmacology, 54 (6), pp. 526-534.
  • Subramani, J., Damodaran, A., Kanniappan, M., Mathuram, L.N. Anti-inflammatory effect of petroleum ether extract of Vitex negundo leaves in rat models of acute and subacute inflammation. (2009) Pharmaceutical Biology, 47 (4), pp. 335-339.
  • Sundaresan, N.R., Marcus Leo, M.D., Subramani, J., Anish, D., Sudhagar, M., Ahmed, K.A., Saxena, M., Tyagi, J.S., Sastry, K.V.H., Saxena, V.K. Expression analysis of melatonin receptor subtypes in the ovary of domestic chicken. (2009) Veterinary Research Communications, 33 (1), pp. 49-56.
  • Gupta, P.K., Subramani, J., Leo, M.D.M., Sikarwar, A.S., Parida, S., Prakash, V.R., Mishra, S.K. Role of voltage-dependent potassium channels and myoendothelial gap junctions in 4-aminopyridine-induced inhibition of acetylcholine relaxation in rat carotid artery. (2008) European Journal of Pharmacology, 591 (1-3), pp. 171-176.
  • Sundaresan, N.R., Anish, D., Sastry, K.V.H., Saxena, V.K., Nagarajan, K., Subramani, J., Leo, M.D.M., Shit, N., Mohan, J., Saxena, M., Ahmed, K.A. High doses of dietary zinc induce cytokines, chemokines, and apoptosis in reproductive tissues during regression. (2008) Cell and Tissue Research, 332 (3), pp. 543-554.
  • Gupta, P.K., Subramani, J., Singh, T.U., Leo, M.D.M., Sikarwar, A.S., Prakash, V.R., Mishra, S.K.  Role of protein kinase G in nitric oxide deficiency-induced supersensitivity to nitrovasodilator in rat pulmonary artery. (2008) Journal of Cardiovascular Pharmacology, 51 (5), pp. 450-456.
  • Kundumani-Sridharan, V., Subramani, J., Owens, C., Walker, T., Wasnick, J., and Das, K.C. Short-duration hyperoxia causes genotoxicity in mouse lungs: Protection by volatile anesthetic isoflurane. (2018), Am J Physiol Lung Cell Mol Physiol., (Submitted).
  • Subramani, J., Kundumani-Sridharan, V., Das, K.C. Novel mechanism of Angiotensin II induced apoptosis: AT2 receptor mediated downregulation of MnSOD expression via ASK-JNK-AP1 axis. (In Preparation).
  • Kundumani-Sridharan, V., Subramani, J., Hilgers, RH. Owens, C., Das, K.C. A novel role for Neuregulin 1 and ErbB2/ErbB4 in endothelium-dependent coronary artery relaxation and remote ischemic preconditioning. (In Preparation).