Venkatesh Kundumani-Sridharan, PhD | Texas Tech University Health Sciences Center

Venkatesh Kundumani-Sridharan, PhD

Venkatesh Kundumani-Sridharan

Venkatesh Kundumani-Sridharan, PhD

Research Assistant Professor, Department of Internal Medicine

Curriculum Vitae

 

 
 
  • Das, K.C., Wasnick, V., and Kundumani-Sridharan, V. Isoflurane inhibits DNA damage signaling in the lungs of mice. Anesth Analg. 120, S-312, 2015. International Anesthesia Research Society Annual Meeting, March 21-24, 2015. Honolulu, Hawaii, USA.
  • Singh, S., Kundumani-Sridharan, V., Kumar, S., Gadepalli, R. and Rao, G. NFATc1 mediates Pak1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall remodeling. FASEB J, 28(1 Supplement), 1158.5, 2014. Experimental Biology 2014, April 26-30, 2014. San Diego, CA, USA
  • Das, K.C., Kundumani-Sridharan, V., Walker, T. and Wasnick, J.D. Effect of hyperoxia in conjunction with isoflurane in the expression of oxidative stress response genes in the heart and lungs of mice. Anesth Analg. 118, S-74, 2014. International Anesthesia Research Society Annual Meeting, March 17-20, 2014. Montreal, Quebec, Canada.
  • Gadepalli, R., Singh, N.K., Kundumani-Sridharan, V., Heckle, M. and Rao, G. Novel Role of Pyk2 in Vascular Wall Remodelling Following Balloon Injury. Circulation. 2012, 126:A14160. American Heart Association 2012 Scientific Sessions and Resuscitation Science Symposium, November 3-7, 2012, Los Angeles, CA, USA.
  • Kundumani-Sridharan, V., Quyen, D.V., Subramani, J., Singh, N.K., and Rao, G.N. Interaction between NFATc1 and STAT3 is required for thrombin-induced cyclin D1 expression in vascular smooth muscle cells. FASEB J, March 29,782.8, 2012. Experimental Biology 2012, April 21-25, 2012. San Diego, CA, USA.
  • Singh, N.K., Kundumani-Sridharan, V., and Rao, G.N. 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. FASEB J, March 26, 26:683.9, 2012. Experimental Biology 2012, April 21-25, 2012. San Diego, CA, USA.
 
  • Hilgers RH*, Kundumani-Sridharan V*, Subramani J, Chen LC, Cuello LG, Rusch NJ, Das KC. 2017. Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function. Sci Transl Med. 9(376): eaaf6094.
  • Subramani J, Kundumani-Sridharan V, Hilgers RH, Owens C, Das KC.  2016. Thioredoxin uses a GSH-independent route to deglutathionylate endothelial nitric-oxide synthase and protect against myocardial infarction. J Biol Chem. 291(45):23374-23389.
  • Kundumani-Sridharan V, Subramani J, Das KC. 2015. Thioredoxin activates MKK4-NFκB pathway in a redox dependent manner to control manganese superoxide dismutase gene expression in endothelial cells. J Biol Chem. 290:17505–17519.
  • Kundumani-Sridharan V, Singh NK, Kumar S, Gadepalli R, Rao GN. 2013. Nuclear factor of activated T cells c1 (NFATc1) mediates p21-activated kinase 1 (Pak1) activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration and proliferation and injury-induced vascular wall remodeling. J Biol Chem. 288:22150-22162.
  • Kundumani-Sridharan V, Dyukova E, Hansen DE 3rd, Rao GN. 2013. 12/15-Lipoxygenase Mediates High-fat Diet-induced Endothelial Tight Junction Disruption and Monocyte Transmigration: a new role for 15(s)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction. J Biol Chem. 288:15830-15842.
  • Singh NK, Hansen DE 3rd, Kundumani-Sridharan V, Rao GN. 2013. Both Kdr and Flt1 play a vital role in hypoxia-induced Src-PLD1-PKCγ-cPLA2 activation and retinal neovascularization. Blood. 121:1911-1923.
  • Gadepalli R, Singh NK, Kundumani-Sridharan V, Heckle MR, Rao GN. 2012. Novel role of proline-rich non-receptor tyrosine kinase 2 in vascular wall remodeling after balloon injury. Arterioscler Thromb Vasc Biol. 32:2652-2661.
  • Singh NK, Kundumani-Sridharan V, Kumar S, Verma SK, Kotla S, Mukai H, Heckle MR, Rao GN. 2012. Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling. J Biol Chem. 287:36291-36304.
  • Kundumani-Sridharan V, Van Quyen D, Subramani J, Singh NK, Chin YE, Rao GN. 2012. Novel interactions between NFATc1 (Nuclear Factor of Activated T Cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G-protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation. J Biol Chem. 287:22463-22482.
  • Singh NK, Kundumani-Sridharan V, Rao GN. 2011. 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation. Blood. 118:5701-5712. Received Editorial Comment (Blood, 118:5367-5369).
  • Singh NK, Wang D, Kundumani-Sridharan V, Van Quyen D, Niu J, Rao GN. 2011. 15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling. J Biol Chem. 286:22478-22488.
  • Zhang Q, Wang D, Singh NK, Kundumani-Sridharan V, Gadiparthi L, Rao ChM, Rao GN. 2011. Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C γ (PKCγ) signaling axis is required for hypoxia-induced pathological retinal angiogenesis. J Biol Chem. 286:22489-22498.
  • Zhang Q, Wang D, Kundumani-Sridharan V, Gadiparthi L, Johnson DA, Tigyi GJ, Rao GN. 2010. PLD1-dependent PKC gamma activation downstream to Src is essential for the development of pathologic retinal neovascularization. Blood. 116:1377-1385. Received Editorial Comment (Blood, 116:1194-1196). Cover Image, Blood, August 26, 2010; 116 (8).
  • Singh NK, Quyen DV, Kundumani-Sridharan V, Brooks PC, Rao GN. 2010. AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. J Biol Chem. 285:16830-16843.
  • Kundumani-Sridharan V, Niu J, Wang D, Van Quyen D, Zhang Q, Singh NK, Subramani J, Karri S, Rao GN. 2010. 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression. Blood. 115:2105-2116.
  • Karpurapu M, Wang D, Van Quyen D, Kim TK, Kundumani-Sridharan V, Pulusani S, Rao GN. 2010. Cyclin D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling. J Biol Chem. 285:3510-3523.
  • Potula HS, Wang D, Quyen DV, Singh NK, Kundumani-Sridharan V, Karpurapu M, Park EA, Glasgow WC, Rao GN. 2009. Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. J Biol Chem. 284:31142-31155.
  • Cheranov SY, Wang D, Kundumani-Sridharan V, Karpurapu M, Zhang Q, Chava KR, Rao GN. 2009. The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8. Blood. 113:6023-6033.
  • Chava KR, Karpurapu M, Wang D, Bhanoori M, Kundumani-Sridharan V, Zhang Q, Ichiki T, Glasgow WC, Rao, GN. 2009. CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. Arterioscler. Thromb. Vasc. Biol. 29:809-815.
  • Zhao T, Wang D, Cheranov SY, Karpurapu M, Chava KR, Kundumani-Sridharan V, Johnson DA, Penn JS, Rao GN. 2009. A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis. J. Lipid Res. 50:521-533.
  • Norseen J, Thomae A, Sridharan V. Aiyar A, Schepers A, Lieberman PM. 2008. RNA-dependent recruitment of the origin recognition complex. EMBO J. 27:3024-3035.
  • Kundumani-Sridharan V, Wang D, Karpurapu M, Liu Z, Zhang C, Dronadula N, Rao GN. 2007. Suppression of activation of signal transducer and activator of transcription-5B signaling in the vessel wall reduces balloon injury-induced neointima formation. Am. J. Pathol. 171:1381-1394.
  • Srivastava K, Kundumani-Sridharan V, Zhang B, Bajpai AK, Rao GN. 2007. 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires STAT3-dependent expression of VEGF. Cancer Res. 97:4328-4336.
  • Wang D, Liu Z, Li Q, Karpurapu M, Kundumani-Sridharan V, Cao H, Dronadula N, Rizvi, F, Bajpai AK, Zhang C, Muller-Newen G, Harris KW, Rao GN. 2007. An essential role for gp130 in neointima formation following arterial injury. Circ. Res. 100:807-816.
  • Kumaresan, N., Sanjay K.R., Venkatesh, K.S., Kadeppagari, R.K., Vijayalakshmi, G. and Umesh-Kumar, S. 2008. Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line. Appl. Microbiol. Biotechnol. 80:467-473.
  • Nakkeeran, E., Venkatesh, K.S., Subramanian, R. and Umesh-Kumar, S. 2008. Purification of Aspergillus carbonarius polygalacturonase using polymeric membranes. J. Chem. Technol. Biotechnol. 83:957-964.
  • Ravi-Kumar, K., Venkatesh, K.S. and Umesh-Kumar, S. 2007. The 53-kDa proteolytic product of precursor starch-hydrolyzing enzyme of Aspergillus niger has Taka-amylase-like activity. Appl. Microbiol. Biotechnol. 74:1011-1015.
  • Ravi–Kumar, K., Venkatesh, K.S. and S. Umesh-Kumar. 2004. Evidence that cleavage of the precursor enzyme by autocatalysis caused secretion of multiple amylases by Aspergillus niger. FEBS Lett. 557:239-242.